Proven science, new opportunities

Photodynamic Therapy: a proven medical treatment, shows new pathogen-fighting promise.

The Singletto team of Photodynamic Therapy (PDT) experts, chemists, virologists, surgeons, and researchers are using Protective Dyes to generate singlet oxygen that destroys pathogens, including the common cold, seasonal flu, and COVID-19. We’re partnering with trusted brands to enhance everyday products with this pathogen-fighting technology.

Photodynamic Therapy

Photodynamic Therapy (PDT) only requires light, oxygen, and color.

Though phototherapy has been used since ancient times in Greece, Egypt, and India, the first major clinical use of Photodynamic Therapy to treat cancer occurred in the 1960s.

Currently, PDT is used to treat many types of cancer (skin, lung, brain, bladder, pancreas, bile duct, esophagus, and head and neck), skin diseases, eye diseases, and more.

PDT can destroy cancer cells through the reaction between light and a photosensitizer. The singlet oxygen produced from this reaction causes cell death in cancer.

Singletto co-Founder, neurosurgeon, and PDT expert Dr. James Chen hypothesized that the concepts of PDT could be applied to the disinfection of pathogens, as well. This hypothesis was tested and confirmed in the Development of Methods for Mask and N95 Decontamination (DeMaND) worldwide study.

Protective Dyes (PDs)

Protective Dyes (PDs) take energy from light sources and transfer the energy to surrounding oxygen; they are used in medical procedures, especially in the fight against cancer.

Certain esophagus and lung cancers are treated with PDT using the PD porfimer sodium (Photofrin). Certain skin conditions are treated with PDT using the PD aminolevulinic acid (ALA or Levulan).  Certain eye conditions are treated with the PD benzporhyrin deriVisudyne.

Methylene Blue (an essential medicine per the WHO) and Riboflavin (Vitamin B2) are Protective Dyes used for plasma disinfection prior to transfusions in some healthcare settings.

The DeMaND study published initially in medRxiv highlights the power of the Protective Dye Methylene Blue in destroying SARS-CoV-2 on soft surfaces.

Singlet Oxygen

Singlet oxygen is well known and well-studied by scientists. Singlet oxygen is created in the environment constantly by sunlight and by many plants (ex: grapefruit, celery, paprika, turnips) and is essential to many biological processes. Singlet oxygen has been shown to destroy pathogens, such as bacteria and viruses.

Protective Dyes can increase singlet oxygen production in the air. These short bursts of energized oxygen can break apart the chemical bonds of harmful pathogens. Singlet Oxygen is extremely short-lived and quickly reverts back to the oxygen that we breathe if not reacting with an immediate target.

Development of Methods for Mask and N95 Decontamination (DeMaND) Study

Singletto Co-Founders Drs. Chen, Lendvay, and Clark, in partnership with the World Health Organization (WHO), the Center for Disease Control (CDC), and 52 total researchers from 13 universities and labs (including the University of Washington, Stanford University, George Washington University, and others), discovered Methylene Blue (a Protective Dye) was a powerful soft surface disinfectant, repeatedly inactivating SARS-CoV-2 on masks and N95 respirators.  The positive results of the DeMaND study were released in 2020 (for full text, view here). The peer-reviewed study can also be found in the Infection Control & Hospital Epidemiology medical journal here.

The main takeaways:

-Methylene Blue with light decontaminated masks and respirators by inactivating three tested coronaviruses (including the coronavirus that causes COVID-19) without compromising material integrity.

- Masks and respirators pre-treated with Methylene Blue were shown to offer ongoing inactivation of coronavirus during use.

-Even in low light settings, the Methylene Blue solution was able to inactivate virus.

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