Singletto Proof of Concept:
Oxafence™ Antimicrobial Soft Surface Disinfectant Spray

A note from Dr. Tom Lendvay, Singletto Chief Medical Officer

Thank you for your participation in this Proof of Concept.

As a pediatric surgeon, my priorities have and always will be health and safety of patients and healthcare professionals. Unfortunately, we have accepted masks and PPE that don’t go far enough in providing safe protection from pathogens. Our gear shouldn’t just trap pathogens, it should kill pathogens. And it should do so perpetually.

I was proud to serve as lead author of the recent 52-researcher, WHO- and CDC-initiated, worldwide study on mask decontamination. I saw first-hand how applying principles of Photodynamic Therapy (PDT) to coronavirus-infected masks and PPE lead to complete … and perpetual … inactivation of virus.

Singletto exists to bring this pathogen-destroying technology to the healthcare sector, and beyond.

The spray you are holding today contains protective dyes that when sprayed on soft surfaces can perpetually inactivate 99.9% of pathogens within five minutes. One application can provide inactivation of pathogens throughout your whole workday. That’s pretty powerful.

But Singletto is much more than a spray. Oxafence in this POC represents a paradigm shift from post-process decontamination to in-use perpetual disinfection.

We constantly face risk of exposure to virus, bacteria, and fungi. Interacting with patient bed sheets, curtains, and gowns … doffing our own gowns, booties, caps, gloves, and masks … touching elevator buttons, railings, machines …

Someday soon, all of these items could contain Oxafence active-protection technology.  We could enjoy the peace of mind that the products and equipment on and around us are actively and perpetually disinfecting themselves.

Hopefully this vision for the future resonates with you. Thank you for being a leader in enhancing the safety of our work environments.

About Singletto

Singletto builds pathogen-destroying singlet oxygen solutions to help you feel free to live well. The Singletto team of Photodynamic Therapy (PDT) experts, chemists, virologists, surgeons, and researchers use protective dyes to generate singlet oxygen that destroys pathogens, including the common cold, seasonal flu, and SARS-CoV-2. We’re partnering with trusted brands to enhance everyday products with this pathogen-fighting technology. Meet our Team.

Oxafence Technology

Oxafence active-protection antimicrobial technology is the latest in pathogen-defense solutions. Most current pathogen protection technologies either trap pathogens or disinfect pathogens after infection. Very few protective technologies exist to actively destroy pathogens during product use or wear. Singletto’s perpetual action technology allows for continual self-disinfection, when used as directed. Learn More about our Technology.

Science and Research

The hundred-year-old medical practice of Photodynamic Therapy (PDT) deploys light and colored dyes to treat cancer and skin conditions. The same principles are now applied in novel ways to provide perpetual protection from dangerous pathogens, even COVID-19. Certain protective dyes have the unique molecular ability to transfer energy from surrounding light to nearby, ever-present oxygen, briefly exciting such to the state of singlet oxygen. Singlet oxygen is well-known for its ability to destroy pathogens, including viruses, bacteria, and fungi. A recent 52-researcher, worldwide WHO-led study confirmed such. View the pre-published study on medRxiv and look for the peer-reviewed study in the Infection Control & Hospital Epidemiology journal soon (in press now).

Indiscriminate Disinfection

Many disinfectants and antimicrobials contribute to the ongoing antimicrobial resistance crisis. Research shows pathogens cannot create resistance to singlet oxygen. Singlet oxygen can destroy pathogens from multiple routes: within the amino acids in spike proteins, in the lipids of membranes, and within the RNA.

Oxafence Spray

Singletto’s Oxafence spray provides continuous, proactive protection from pathogens, when used as described.

Shake gently before each use. Spray eight (8) pumps on soft surfaces, or until thoroughly covered. Allow to dry.

Apply with care. May cause discoloration of fabrics and surfaces. Spills or leaks from the bottle may result in unwanted staining of surfaces. Avoid excessive overspray when applying the product. Store the bottle in a cool, dry, and dark location. Avoid excessive or ongoing exposure to light during storage. For external use only, do not spray the product on humans or animals. Do not ingest the product. If ingestion occurs, please contact your physician. Keep this product out of reach of children.

Product Information

Oxafence is an FDA Class 1 Antimicrobial Disinfectant Spray (3018759584). Registered for use on soft surfaces. This Oxafence spray’s active ingredient is Methylene Blue. This product is not to be used on any surface or instrument that (1) is introduced directly into the human body, either into or in contact with the bloodstream or normally sterile areas of the body, or (2) contacts intact mucous membranes but which does not ordinarily penetrate the blood barrier or otherwise.

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