SEATTLE – The World Health Organization (WHO) just added Methylene Blue and Light as a supported Personal Protective Equipment (PPE) decontamination method in the “Rational use of personal protective equipment for COVID-19 and considerations during severe shortages” interim guidelines.
Making its first update to these PPE guidelines since April 2020, the WHO provided updated strategies for optimizing PPE use by health workers caring for patients with suspected, probable, and confirmed COVID-19, including a new section for PPE decontamination and reprocessing considerations.
The updated guidelines now state:
MBL (Methylene Blue and Light) and DH (Dry Heat) were applied to respirators and medical mask materials to test inactivation of SARS-CoV-2 and surrogate coronaviruses. The study found that both MBL and DH consistently killed SARS-CoV-2, with some heterogeneity in DH values. The findings suggest MBL could potentially be developed as a new reprocessing method.
The Development of Methods for Mask and N95 Decontamination (DeMaND) Study, cited by the WHO, sought to determine simple, efficient, and inexpensive methods to reprocess SARS-CoV-2-exposed medical masks and respirators. The study showed for the first time how Methylene Blue (MB), a common light-activated dye (LAD), can be applied to masks and other personal protective equipment (PPE) to both decontaminate coronavirus-infected PPE and provide continuous inactivation of the virus.
The DeMaND Study was led by Singletto co-founders Drs. Thomas Lendvay and James Chen in collaboration with esteemed colleagues in a consortium of worldwide labs assembled through the WHO COVID-19 Task Force. Singletto has continued research into this breakthrough method, now conducting five follow-up studies in its Singletto labs around North America.
Drs. Lendvay and Chen, along with Singletto co-founder Dr. Tanner Clark, Virologist Dr. David Evans, Arbovirologist Dr. Chris Mores, Immunologist and Virologist Dr. Michael Gale, and Photochemist Dr. Belinda Heyne are leading the research – working to develop further technological advances that will make our healthcare community, and community at large, better prepared to safely fight pathogens.
Singletto provides the novel solutions needed to face the important medical and health challenges of today and tomorrow. Singletto builds pathogen-destroying singlet oxygen solutions to help you feel free to live well. Singletto works with healthcare-focused and general consumer brands and manufacturers to provide solutions for their existing and future products, technology, and systems by licensing its proprietary OxyFence™ technology. Singletto is seeking EUA (Emergency use Authorization) approval for certain use-cases of this technology for immediate COVID-19 relief.
For more information about the DeMaND Study, visit https://www.medrxiv.org/content/10.1101/2020.12.11.20236919v1
For more information about Singletto, visit www.Singletto.com
Singletto Contact: Media@Singletto.com
Dr. Belinda Heyne was recently featured in a CBC piece covering the DeMaND study’s findings and the life-giving potential of dye and light.
The World Health Organization (WHO) just added Methylene Blue and Light as a supported Personal Protective Equipment (PPE) decontamination method in the “Rational use of personal protective equipment for COVID-19 and considerations during severe shortages” interim guidelines.
Arbovirologist, professor, and GWU lab director Dr. Chris Mores has just returned from Africa, supporting local and international field teams in the fight against Ebola in the DRC. Though COVID-19 has taken center stage over the last year, it’s important to remember other deadly viruses haven’t taken a day off. More with Chris Mores on fighting pathogens around the world.
After years of fundamental research on photosensitizers, Belinda Heyne, Ph.D, now applies concepts of photochemistry and photobiology to the fight against pathogens. Her expertise and her lab’s unique ability to measure singlet oxygen directly make her critically important to Singletto’s ongoing research efforts and technology development. More with expert Belinda Heyne.
In collaboration with the WHO, CDC, and a consortium of labs around the world, Singletto founders Drs. Chen, Lendvay and Clark, conducted extensive research on the decontamination effects of the light-activated dye Methylene Blue on viruses, including SARS-CoV-2. The positive results of such study have been pre-published on medRxiv. Watch our video to learn more.